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Selasa, 25 Desember 2012

EXCRETORY SYSTEM



Excretory system
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The excretory system is a passive biological system that removes excess, unnecessary materials from an organism, so as to help maintain homeostasis within the organism and prevent damage to the body. It is responsible for the elimination of the waste products of metabolism as well as other liquid and gaseous wastes, as urine and as a component of sweat and exhalation.
Excretion is the name given to the removal from the body of ( 1) the  waste products of its chemical reactions, ( 2 ) the excess water and salts taken in with the diet and ( 3 ) spent hormone.
Excretion also includes the removal of drugs or other foreign substances taken into the alimentary canal and absorbed by the blood.
Excretory organs are lungs, kidneys, liver, and skin.
The Lungs supply the body with oxygen, but they’re also excretion organs because they get rid of the carbon dioxide. They also lose a great deal of water vapor, but this loss is unavoidable and is not a method of controlling the water content of the body.
The Kidneys remove urea and other nitrogenous waste from the blood. They also expel excess water, salt, hormones, and drugs.
There are vesica felea in the liver. The yellow/green bile pigment, bilirubin, is a breakdown product of hemoglobin. Bilirubin is excretion with the bile into the small intestine and expelled with the faeces. The pigment undergoes changes in the intestine and is largely responsible for the brown color of the faeces.
Sweat consists of water, with sodium chloride and traces of urea dissolved in it. When you  sweat, you will expel these substances from your body and so, in one sense, they are being excreted. However, sweating is a response to a rise in temperature and not to a change in the blood composition. I      n this sense, therefore, skin is not an excretory organs like the lungs and kidneys.

Excretory functions
The excretory system removes metabolic and liquid toxic wastes as well as excess water from the organism, in the form of urine.
The excretory system is a passive biological system that removes excess and unnecessary materials from an organism, so as to help maintain homeostasis within the organism and prevent damage to the body.
It is responsible for the elimination of the waste products of metabolism as well as other liquid and gaseous wastes. As most healthy functioning organs produce metabolic and other wastes, the entire organism depends on the function of the system; however, only the organs specifically for the excretion process are considered a part of the excretory system.
As your body performs the many functions that it needs in order to keep itself alive, it produces wastes. These wastes are chemicals that are toxic and that if left alone would seriously hurt or even kill you.
For example, as your cells break down amino acids, they produce a dangerous toxin known as ammonia. Your liver converts the ammonia to another substance, called urea. The urea is turned into urine in the kidneys and is then carried in the ureters to the bladder.
Component organs
Skin is an excretory organ. Although regulation of body temperature causes it to produce sweat which contain urea and other waste with salts too but the secretion of any type of waste for any purpose from the body is called excretion even if it is surplus water.
Lungs
Main article: Lungs
One of the main functions of the lungs is to diffuse gaseous wastes, such as carbon dioxide, from the bloodstream as a normal part of respiration.
Kidneys
Main article: Kidneys
The kidney's primary function is the elimination of waste from the bloodstream by production of urine. They perform several homeostatic functions such as:-
  1. Maintain volume of extracellular fluid
  2. Maintain ionic balance in extracellular fluid
  3. Maintain pH and osmotic concentration of the extracellular fluid.
  4. Excrete toxic metabolic by-products such as urea, ammonia, and uric acid.
The way the kidneys do this is with nephrons. There are over 1 million nephrons in each kidney, these nephrons act as filters inside the kidneys. The kidneys filter needed materials and waste, the needed materials go back into the bloodstream, and unneeded materials becomes urine and is gotten rid of.
In some cases, excess wastes crystallize as kidney stones. They grow and can become a painful irritant that may require surgery or ultrasound treatments. Some stones are small enough to be forced into the urethra.
Ureter
The ureters are muscular ducts that propel urine from the kidneys to the urinary bladder. In the human adult, the ureters are usually 25–30 cm (10–12 in) long. In humans, the ureters arise from the renal pelvis on the medial aspect of each kidney before descending towards the bladder on the front of the psoas major muscle. The ureters cross the pelvic brim near the bifurcation of the iliac arteries (which they run over). This "pelviureteric junction" is a common site for the impaction of kidney stones (the other being the uteterovesical valve). The ureters run posteriorly on the lateral walls of the pelvis. They then curve anteriormedially to enter the bladder through the back, at the vesicoureteric junction, running within the wall of the bladder for a few centimeters. The backflow of urine is prevented by valves known as ureterovesical valves. In the female, the ureters pass through the mesometrium on the way to the bladder.
Urinary bladder
The urinary bladder is the organ that collects urine excreted by the kidneys prior to disposal by urination. It is a hollow muscular, and distensible (or elastic) organ, and sits on the pelvic floor. Urine enters the bladder via the ureters and exits via the urethra.
Embryologically, the bladder is derived from the urogenital sinus, and it is initially continuous with the allantois. In human males, the base of the bladder lies between the rectum and the pubic symphysis. It is superior to the prostate, and separated from the rectum by the rectovesical excavation. In females, the bladder sits inferior to the uterus and anterior to the vagina. It is separated from the uterus by the vesicouterine excavation. In infants and young children, the urinary bladder is in the abdomen even when empty.
Urethra
In anatomy, the (from Greek - ourethra) is a tube which connects the urinary bladder to the outside of the body. In humans, the urethra has an excretory function in both genders to pass .

Urine formation
For the production of urine, the kidneys do not simply pick waste products out of the bloodstream and send them along for final disposal. The kidneys' 2 million or more nephrons (about a million in each kidney) form urine by three precisely regulated processes: filtration, reabsorption, and secretion.

Filtration

Figure 3. Urine formation takes place in the nephron.
Urine formation begins with the process of filtration, which goes on continually in the renal corpuscles (Figure 3). As blood courses through the glomeruli, much of its fluid, containing both useful chemicals and dissolved waste materials, soaks out of the blood through the membranes (by osmosis and diffusion) where it is filtered and then flows into the Bowman's capsule. This process is called glomerular filtration. The water, waste products, salt, glucose, and other chemicals that have been filtered out of the blood are known collectively as glomerular filtrate. The glomerular filtrate consists primarily of water, excess salts (primarily Na+ and K+), glucose, and a waste product of the body called urea. Urea is formed in the body to eliminate the very toxic ammonia products that are formed in the liver from amino acids. Since humans cannot excrete ammonia, it is converted to the less dangerous urea and then filtered out of the blood. Urea is the most abundant of the waste products that must be excreted by the kidneys. The total rate of glomerular filtration (glomerular filtration rate or GFR) for the whole body (i.e., for all of the nephrons in both kidneys) is normally about 125 ml per minute. That is, about 125 ml of water and dissolved substances are filtered out of the blood per minute. The following calculations may help you visualize how enormous this volume is. The GFR per hour is:
125 ml/min X 60min/hr= 7500 ml/hr. The GFR per day is:
7500 ml/hr X 24 hr/day = 180,000 ml/day or 180 liters/day.
Now, see if you can calculate how many gallons of water we are talking about. Here are some conversion factors for you to consider: 1 quart = 960 ml, 1 liter = 1000 ml, 4 quarts. = 1 gallon. Remember to cancel units and you will have no problem. Now, what we have just calculated is the amount of water that is removed from the blood each day - about 180 liters per day. (Actually it also includes other chemicals, but the vast majority of this glomerular filtrate is water.) Imagine the size of a 2-liter bottle of soda pop. About 90 of those bottles equals 180 liters! Obviously no one ever excretes anywhere near 180 liters of urine per day! Why? Because almost all of the estimated 43 gallons of water (which is about the same as 180 liters - did you get the right answer?) that leaves the blood by glomerular filtration, the first process in urine formation, returns to the blood by the second process - reabsorption.

Reabsorption

Reabsorption, by definition, is the movement of substances out of the renal tubules back into the blood capillaries located around the tubules (called the peritubular copillaries). Substances reabsorbed are water, glucose and other nutrients, and sodium (Na+) and other ions. Reabsorption begins in the proximal convoluted tubules and continues in the loop of Henle, distal convoluted tubules, and collecting tubules (Figure 3). Let's discuss for a moment the three main substances that are reabsorbed back into the bloodstream. Large amounts of water - more than 178 liters per day - are reabsorbed back into the bloodstream from the proximal tubules because the physical forces acting on the water in these tubules actually push most of the water back into the blood capillaries. In other words, about 99% of the 180 liters of water that leave the blood each day by glomerular filtration returns to the blood from the proximal tubule through the process of passive reabsorption. The nutrient glucose (blood sugar) is entirely reabsorbed back into the blood from the proximal tubules. In fact, it is actively transported out of the tubules and into the peritubular capillary blood. None of this valuable nutrient is wasted by being lost in the urine. However, even when the kidneys are operating at peak efficiency, the nephrons can reabsorb only so much sugar and water. Their limitations are dramatically illustrated in cases of diabetes mellitus, a disease which causes the amount of sugar in the blood to rise far above normal. As already mentioned, in ordinary cases all the glucose that seeps out through the glomeruli into the tubules is reabsorbed into the blood. But if too much is present, the tubules reach the limit of their ability to pass the sugar back into the bloodstream, and the tubules retain some of it. It is then carried along in the urine, often providing a doctor with her first clue that a patient has diabetes mellitus. The value of urine as a diagnostic aid has been known to the world of medicine since as far back as the time of Hippocrates. Since then, examination of the urine has become a regular procedure for physicians as well as scientists. Sodium ions (Na+) and other ions are only partially reabsorbed from the renal tubules back into the blood. For the most part, however, sodium ions are actively transported back into blood from the tubular fluid. The amount of sodium reabsorbed varies from time to time; it depends largely on how much salt we take in from the foods that we eat. (As stated earlier, sodium is a major component of table salt, known chemically as sodium chloride.) As a person increases the amount of salt taken into the body, that person's kidneys decrease the amount of sodium reabsorption back into the blood. That is, more sodium is retained in the tubules. Therefore, the amount of salt excreted in the urine increases. The process works the other way as well. The less the salt intake, the greater the amount of sodium reabsorbed back into the blood, and the amount of salt excreted in the urine decreases.

Secretion

Now, let's describe the third important process in the formation of urine. Secretion is the process by which substances move into the distal and collecting tubules from blood in the capillaries around these tubules (Figure 3). In this respect, secretion is reabsorption in reverse. Whereas reabsorption moves substances out of the tubules and into the blood, secretion moves substances out of the blood and into the tubules where they mix with the water and other wastes and are converted into urine. These substances are secreted through either an active transport mechanism or as a result of diffusion across the membrane. Substances secreted are hydrogen ions (H+), potassium ions (K+), ammonia (NH3), and certain drugs. Kidney tubule secretion plays a crucial role in maintaining the body's acid-base balance, another example of an important body function that the kidney participates in.

Summary

In summary, three processes occurring in successive portions of the nephron accomplish the function of urine formation:
  1. Filtration of water and dissolved substances out of the blood in the glomeruli and into Bowman's capsule;
  2. Reabsorption of water and dissolved substances out of the kidney tubules back into the blood (note that this process prevents substances needed by the body from being lost in the urine);
  3. Secretion (augmentation)of hydrogen ions (H+), potassium ions (K+), ammonia (NH3), and certain drugs out of the blood and into the kidney tubules, where they are eventually eliminated in the urine.

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